Article: Neuronal correlates in PTSD

Neuronal correlates in PTSD: Study of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post–traumatic stress disorder.

To reveal the pathogenesis of PTSD, Guo et al. (2012) used magnetic resonance spectroscopy (MRS,  more precisely 3D 1H-MRS) to determine the chemical composition of particlular areas in vivo. In a total of 100 people (50 in control group, 50 in PTSD group). Significant Metabolic abnormalities were found in the anterior cingulate gyrus: the PTSD group showed lower NAA/Cr ratios and higher Cho/Cr ratios. NAA/Cr ratios were significantly lower in the PTSD group in the hippocampus as well. These results suggest special neurochemical changes in PTSD patients.

Guo, M., Chen, F., Guo, J.-C., Lu, C.-Z., Jiang, X.-L., Liu, T., … (2012). Study of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post–traumatic stress disorder. Asian Pacific Journal of Tropical Medicine, 5(2), 162–164. doi:10.1016/S1995-7645(12 )60017-0