Latest study on common genetic factors for differe...

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Past research has shown that psychiatric disorders are moderately to highly heritable, but there is currently no conclusion to which extent the genetic variations are unique to individual disorders or shared across different disorders.

The Cross-Disorder Group of the Psychiatric Genomics Consortium examined these genetic variations for schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders and attention-deficit/hyperactivity disorder in a very large sample.

They found evidence for moderately to highly shared genetic variations across schizophrenia, bipolar disorder and major depressive disorder. Further, there are also shared genetic variations between ADHD and major depressive disorder. A low correlation was found between schizophrenia and ASD.  Overall their analysis suggests a shared genetic contribution for both types of disorders with 1) onset in the childhood (attention deficit/hyperactivity disorder, autism spectrum disorder) and 2) disorders usually diagnosed after childhood (schizophrenia, bipolar disorder, major depression), with moderately shared variations between the two groups.

It would be an interesting research question for the future to know which genetic variations of trauma-related disorders are shared with other disorders.


Read the full article in Nature Genetics.