Early life stressors and genetic influences on the...

Although there is increasing research exploring the psychosocial influences and biological underpinnings of bipolar disorder, relatively few studies have specifically examined the interplay between these factors in the development of this illness. Social–biological models within a developmental psychopathology perspective are necessary to advance our understanding of the processes involved in the onset and course of bipolar disorder. This article presents a review of the empirical literature linking childhood abuse to bipolar disorder, the research to date on the possible role of brain-derived neurotrophic factor (BDNF) in the development of this disorder, followed by a discussion of how childhood abuse may interact with BDNF.

Author: Richard T. Liu
Doi: doi:10.1016/j.chiabu.2009.10.009
Source: http://www.sciencedirect.com/science/journal/01452134