Article: PTSD – Fear conditioning, synaptic ...

This article reviews how the neural circuitry implicated in Posttraumatic stress disorder (PTSD) in humans is related to the neural circuitry of fear. Then authors discuss how fear conditioning is a suitable model for studying the molecular mechanisms of the fear components that underlie PTSD, and the biology of fear conditioning with a particular focus on the brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB), GABAergic and glutamatergic ligand-receptor systems. The authors conclude how such approaches might help to inform our understanding of PTSD and other stress-related disorders and provide insight to new pharmacological avenues of treatment of PTSD.

Mahan, A. L., & Ressler, K. J. (2012). Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends in Neurosciences, 35 (1), 24-53.

doi: 10.1016/j.tins.2011.06.007